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Milithin 300 mg daily for 4 weeks in 8 patients with moderate to severe plaque psoriasis and moderate to severe atopic dermatitis. The patients demonstrated a dramatic relief of their psoriasis-caused scaring with a reduction in scores from mean of 18.4 to 7.8 and a decrease in pain intensity. [3] Silymarin 1 g daily for 4 weeks in 12 individuals with moderate to severe plaque-type psoriasis. The patients responded by a marked improvement in their psoriasis scores, with improvements in their itch scores and reduced dryness. [4] In an uncontrolled study, 1.25 g of silymarin daily in 5, 9 or 21-year-olds with mild to moderate psoriasis at 2- 4-month intervals for 3 months. Patients treated with silymarin demonstrated improvement of psoriatic and seborrheic areas on a scale from 0 to 100. They also had a reduced incidence of skin infections, improved overall self-attention, fewer dry lesions, and erythema erythematous papules on their skin. [5] 1 tablespoon of silymarin daily in 12 adult women with moderate to severe plaque psoriasis who did not use topical steroids. The patients showed improvement in their psoriasis as demonstrated by a large reduction in their scaring score from 18.3 to 3.1. The patients rated their feelings of well-being as decreased and rated their overall health as improved. mean scores for quality of life were also rated to be improved. [6, 7] In a small open-label trial 17 adult patients who experienced worsening of psoriasis with steroid therapy, 5 grams of silymarin daily for 12 weeks significantly improved the mean Psoriasis Area and Severity Index scores the self-assessed of their depression, anger, fatigue, and stress as measured by the Hamilton Depression Rating Scale. [8] Silymarin is an antiinflammatory substance found in marine foods.[9] Many patients report use of silymarin to control their psoriasis and other inflammatory dermatoses. However, because of its effects on psoriasis, silymarin may interact with certain drugs and is contraindicated in patients with a history of allergy to silymarin. Vitamin D The relationship between psoriasis and low vitamin D levels is largely unknown. As far back the 1980s, some researchers suggested that vitamin D deficiency may be responsible for the symptoms of psoriasis []. A 2012 study revealed that psoriasis may increase a person's risk of having impaired vitamin D functioning. [10] Researchers found that vitamin D deficiencies in a group of 8,000 people with psoriasis were found to double their risk of developing psoriatic arthritis and increase an estimated 20 times the risk of developing type 2 diabetes. [11] To test whether or not higher levels of vitamin D might improve the appearance of psoriasis, researchers enrolled 40 men and women with psoriasis 30 healthy controls. Both groups had average baseline vitamin D levels between 40 ng/ml and 80 ng/ml, but those with psoriasis showed reduced levels and those who did not had similar vitamin D levels. The results showed that those patients with psoriasis who underwent daily use of sunlamp were significantly less likely to develop psoriasis within the next year compared to their placebo counterpart. [12] Other studies have reported an increased risk of psoriatic disease associated with a person's vitamin D levels and found that vitamin D supplementation can lower overall disease incidence for people with type 2 diabetes. In addition, lower vitamin D levels were associated with more severe disease in those with psoriasis and were associated lessening levels of the body's endogenous vitamin D production. For people of normal weight, the body produces its own vitamin D which increases with age and is increased by sun exposure. One 2011 study showed that vitamin D supplementation, particularly of 3. Supplementation to older adults with psoriasis reduced the severity of their disease. They also had less severe flares and fewer skin lesions other signs of inflammatory changes. The authors suggest that these positive effects of sun protection are due to improved vitamin D and 3 -3 metabolites in addition to a decreased risk of subsequent flares. [13] Another study found that psoriasis patients who were given an oral vitamin D 3 -supplement had a 25 percent reduction in plaque score, whereas placebo-treated patients did not. [14] Omega-3s Several studies have demonstrated the benefit of omega-3 supplementation in patients global pharmacy canada coupon code who were diagnosed with psoriasis. [15, 16, 17] Researchers found that omega-3 treatment improved patients' skin characteristics as measured by Psoriasis Area and Severity Index that patients reported improvements. [15,]

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