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915.109- P - foto
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*- Set locks for roller shatters , twe-sided locking.
*- Schita si dimensiuni de gabarit:
155 mm x 139 mm.
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Broasca garaj -915.109 P - schita 2 directii
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*- Inchidere pe 2 directii / two-sided locking/ stanga-dreapta.
*- material: otel.
*- Protectii anti-drilling /la modelul 915.109-P.
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Broasca garaj o directie -915.110- P_ foto
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*- Broasca pentru garaj 915.110 P.
*- Se livreza in set: stanga+dreapta.
*- Dimensiuni de gabarit: 155 x 60 mm.
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915.109 P - schita
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*- Yala aplicata /broasca/ pentru garaj -cu incuiere pe 2 directii, schita cu dimensiuni.
*- codul 915.109 P are si protectie antidrill pentru cilindru.
*- schita cu dimensiuni.
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Propecia cost us over a period of five years. As a result, our revenues for the years ended December 31, 2011, 2010, and 2009, were substantially reduced.
During the second quarter of 2010, we initiated a multi-year, strategic investment in our research and development platform by acquiring the U.S.-based company, Reteia Inc., and the European-based company, Synagen Corp. acquisition of Reteia and the Synagen, which took place during the third quarter of 2010, increased our research and development activities worldwide.
We continued to invest in our research and development platform into the fourth quarter of 2010, when we announced the ongoing completion of Phase 3 the 2 clinical trial of a new drug candidate, nivolumab. During the fourth quarter of 2010, we successfully completed a Phase 2 clinical trial of a second nivolumab drug candidate, and also reported positive results in the first Phase 2 clinical trial of nivolumab.
During the fourth quarter of 2010, we also announced the commencement of our ongoing Phase 2 clinical trial of another drug candidate in clinical development. The drug candidate is also in Phase 2 clinical development. Upon the conclusion of Phase 2 clinical trial this drug candidate in the fourth quarter of 2012, it was expected that we would pursue commercialization of this drug candidate. As December 31, 2012, the total estimated sales benefit is more than $16.4 million.
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We measure our results of operations by the operating segments we operate in as of the end a reporting period. For the years ended December 31, 2011, 2010, and 2009, we reported our results on a net sales basis.
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We primarily develop therapies for patients with blood vessel diseases. Our focus is on Phase 1 clinical trials of nivolumab, a novel unmet medical need drug candidate for the treatment of patients with metastatic liver cancer. In recent years, the development of nivolumab has been supported by grants and contracts from the National Institutes of Health and commercial relationships with GlaxoSmithKline, Roche, and Teva.
In September 2010, we announced the commencement of clinical trials for a second nivolumab drug candidate, oncolytic nivolumab, in patients with multiple myeloma. August 2011, we announced the commencement of similar clinical trials for our other in-house branded biologics portfolio in patients with leukemias. November 2011, we entered into a co-marketing agreement for oncolytic nivolumab and a biologic drug candidates, brincidofovir, and dasatinib, with Teva the Swiss drug company, Novartis.
In February 2012, we announced the successful completion of clinical trials for an investigational drug candidate that is being developed for the treatment of lung cancer.
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Research and development expenses consist primarily of salaries, stock-based compensation, related facilities costs, and research development allowances. expenses for the years ended December 31, 2011, 2010, and 2009, were approximately $2.3 million, $4.8 and $4.2 respectively. As of December 31, 2012, we had $40.2 million of research and development expense related to our in-house branded biologics portfolio.
Our research and development activities support our of biologic drugs for the treatment of certain diseases. In the development of in-house branded biologics portfolio, we are developing clinical trials for a number of investigational drug candidates through which we hope to obtain regulatory clearance seek approval for a new drug, including the in-house branded biologics.
Research and development expenses for the years ended December 31, 2010, and 2009, were approximately $1.6 million, $1.7 and $2.3 respectively. As of December 31, 2012, we had $21.5 million of research and development expense related to our in-house branded biologics portfolio.
Research and development expenses for the years ended December 31, 2011, and 2010, included expenses related to the development and commercialization of one our in-house branded biologics, bortezomib, for the treatment of osteoporosis.
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