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Cymbalta 30 mg dosage form and a single-tablet dosage form, as shown in Table 7.8. This dose is not recommended in patients with liver disease or taking anticonvulsants, as it may lead to liver damage if the anticonvulsant is taken with methylphenidate.
Table 7.8: Combinations of ADHD and Methylphenidate
Combinations of ADHD and Methylphenidate Single Tablet Tablets ADHD 1 mg = 25 Tablets 50 or 10 mg =
Methylphenidate tablets should not be used in combination with other cymbalta dosage central nervous system depressants, including phenothiazines and tricyclic antidepressants.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Carcinogenesis
Carcinogenic properties have been determined for the use of methylphenidate (Dipropion, Ritalin). An in vitro and a field study of rat brain cells revealed that chronic administration of 100, 200, and 400 mg/kg/day doses of methylphenidate (Dipropion) for 6 to 12 months produced an increase in serum creatinine male rats of generic cymbalta price approximately 2.4- to 5.1-fold with the highest dose and approximately 4-fold with the 200- and 400-mg/kg/day doses highest dose was not more effective in increasing the incidence of kidney stones than 200mg/kg/day.
Methylphenidate has not been determined to be a carcinogen, but the dose-dependent effects of methylphenidate on lung cancer, hepatobiliary tumor multiplicity, and the incidence of leukemia in rats and mice are consistent with carcinogenic properties.
Mutagenesis
No mutagenic potential was observed in vitro for any of the tested methylphenidate metabolites in vitro at doses up to 100,000 and 20,000 mg/L for M1 M2 amino-methylphenidate, respectively. Methylphenidate-mimetic compounds were not mutagenic at doses up to 100,000 and 20,000 mg/L for M1 M2 amino-methylphenidate, respectively. The effects of phentermine on chromosomal analysis are consistent with a reduction of chromosome breaks and DNA double-strand with prolonged oral administration.
Impairment of Fertility
Methylphenidate in the United States and Canada is authorized for use only the treatment of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents 6 to 17 years of age. In the United Kingdom use of methylphenidate is authorized and restricted for the treatment of children and adolescents only.
Studies in animal models have confirmed that chronic, repeated oral administration of methylphenidate in doses up to 100 mg/kg/day for 12 weeks is associated with neurobehavioral and adverse hormonal changes, and, ultimately, reduced fertility as well an increased incidence of malignant tumors. Studies in rats demonstrated that oral administration of high doses methylphenidate causes severe impairment of fertility, and this was associated with reduced fertility repeated doses of methylphenidate up to several thousand times greater than the doses in humans. effect of methylphenidate on fertility was not blocked by a tamoxifen-like substance or blocker. The effect of tamoxifen-like agent was partially prevented by.
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MAUER- Slot Spray- Aplicatii
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*- Aplicatii MAUER_Intretinerea cilindrilor MAUER-
Sfaturi : >> Acasa: pentru toate incuietorile usilor, yalelor, cilindrilor /butuci/, balamalelor.
*- Auto: incuietori, cilindri, balamale, etc.
*- Diverse: scule, dispozitive.
*- Protectie impotriva ruginei si a coroziunii.
*- Dezghetarea mecanismelor.
*- Gresarea se face anual.
*- Vizate sunt "CLANTA " si "ZAVORUL ;.
*- Imaginea alaturata identifica mecanismele marcate cu ROSU.
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Spray pentru incuietori , yale, mecanisme fine
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*- MAUER _ Slot Spray: - Aplicatii: -Ungerea mecanismelor incuietorilor, yalelor, cilindrilor de siguranta.
*- Protectie impotriva ruginei si a coroziunii.
*- Curatirea mecanismelor fine.
*- Protectie impotriva aburului.
*- Protectie impotriva inghetului.
*- Dezghetarea mecanismelor si incuietorilor.
*- Zonele care trebuie sa fie gresate anual, in detaliu.
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Instructiuni de utilizare Cilindri
> Instructiuni de utilizare pentru Cilindrii MAUER .
> NU introduceti cheia la ambele capete,simultan.
> NU fortati chei indoite , incovoiate.
> Cilindrul poate iesi in afara sildului maxim 3 mm .
> NU fortati cheia cu scule.
> NU utilizati capul capisonul pe post de cheie.
> Preveniti fortele orizontale , pe post de tragere sau impingere.
> Nu fortati cilindrul in broasca.
> Introduceti in cilindru NUMAI cheia potrivita. Nu introduceti alte obiecte.
> Lubrifiati cilindrul regulat, aprox 1-2 ori pe an.
> FOLOSITI lubrifiant MAUER -Spray care nu corozeaza !!!
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